| Protein Name | vitamin K epoxide reductase complex subunit 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 79001 |
| Gene Symbol | VKORC1 |
| UniProt | Q9BQB6 (VKOR1_HUMAN), A0A0S2Z5X7 (A0A0S2Z5X7_HUMAN), A0A0S2Z6I4 (A0A0S2Z6I4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
133
Total Number of Articles : 847 |
Description |
vitamin K epoxide reductase complex subunit 1 |
| Gene Summary |
This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
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| Properties | |