Protein Name vitamin K epoxide reductase complex subunit 1
Organism Homo sapiens
Gene ID 79001
Gene Symbol


UniProt Q9BQB6 (VKOR1_HUMAN), A0A0S2Z5X7 (A0A0S2Z5X7_HUMAN), A0A0S2Z6I4 (A0A0S2Z6I4_HUMAN)
Relationships Total Number of functionally related compound(s) : 133
Total Number of Articles : 847

vitamin K epoxide reductase complex subunit 1

Gene Summary

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

  • vitamin K epoxide reductase complex subunit 1
  • phylloquinone epoxide reductase
  • vitamin K dependent clotting factors deficiency 2
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