Pub. Date : 2019 May 31
PMID : 30038060
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The SLC34A2-ROS-HIF-1-induced up-regulation of EZH2 expression promotes proliferation and chemo-resistance to apoptosis in colorectal cancer. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Reactive oxygen species (ROS) generation contributed to the stabilization of HIF-1alpha by leading to the binding of HIF-1alpha to the EZH2 promoter, which resulted in increased EZH2 expression. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Reactive oxygen species (ROS) generation contributed to the stabilization of HIF-1alpha by leading to the binding of HIF-1alpha to the EZH2 promoter, which resulted in increased EZH2 expression. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Reactive oxygen species (ROS) generation contributed to the stabilization of HIF-1alpha by leading to the binding of HIF-1alpha to the EZH2 promoter, which resulted in increased EZH2 expression. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | Reactive oxygen species (ROS) generation contributed to the stabilization of HIF-1alpha by leading to the binding of HIF-1alpha to the EZH2 promoter, which resulted in increased EZH2 expression. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 6 | SLC34A2-ROS-HIF-1-EZH2 signaling pathway might serve as a novel therapeutic target against CRC. | Reactive Oxygen Species | hypoxia inducible factor 1 subunit alpha | Homo sapiens |