Pub. Date : 2018 Jul 20
PMID : 30037040
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones. | Chalcones | kelch like ECH associated protein 1 | Homo sapiens |
| 2 | Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2. | Chalcones | kelch like ECH associated protein 1 | Homo sapiens |
| 3 | Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2. | Chalcones | kelch like ECH associated protein 1 | Homo sapiens |
| 4 | Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2. | Chalcones | kelch like ECH associated protein 1 | Homo sapiens |
| 5 | In this review we summarize the current progress in the study of Keap1/Nrf2-ARE pathway activation by natural and synthetic chalcones and their potential pharmacological applications. | Chalcones | kelch like ECH associated protein 1 | Homo sapiens |