Pub. Date : 2018 Aug
PMID : 30033448
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiopoietin-like protein 3 blocks nuclear import of FAK and contributes to sorafenib response. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 2 | Loss-of-function and gain-of-function experiments were performed to investigate the biological roles of ANGPTL3 in response to sorafenib treatment in RCC cells. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 3 | RESULTS: ANGPTL3 was upregulated in sorafenib-responsive RCC, which correlated with clinically good sorafenib response. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 4 | RESULTS: ANGPTL3 was upregulated in sorafenib-responsive RCC, which correlated with clinically good sorafenib response. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 5 | Knockdown of ANGPTL3 conferred sorafenib-tolerance traits to RCC cells, whereas overexpression of ANGPTL3 restored sorafenib sensitivity in RCC cells. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 6 | Mechanistically, ANGPTL3 bound to Focal Adhesion Kinase(FAK) and restained sorafenib induced nuclear translocation of FAK, leading to attenuate the ubiquitination of p53, which contributed to cellular apoptosis and enhanced sorafenib response. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 7 | Mechanistically, ANGPTL3 bound to Focal Adhesion Kinase(FAK) and restained sorafenib induced nuclear translocation of FAK, leading to attenuate the ubiquitination of p53, which contributed to cellular apoptosis and enhanced sorafenib response. | Sorafenib | angiopoietin like 3 | Homo sapiens |
| 8 | CONCLUSIONS: ANGPTL3 may be a novel predictor for the response of sorafenib therapy in RCC patients, and a potential target in improving its therapeutic effect. | Sorafenib | angiopoietin like 3 | Homo sapiens |