Pub. Date : 2018 Nov
PMID : 30031824
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-kappaB, and the induction of autophagy. | daphnetin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Moreover, Daph treatment effectively inhibited LPS/GalN-induced nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathway activation, and significantly induced autophagy activation by enhancing the level of pro-autophagy proteins expression. | daphnetin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Moreover, Daph treatment effectively inhibited LPS/GalN-induced nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathway activation, and significantly induced autophagy activation by enhancing the level of pro-autophagy proteins expression. | daphnetin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 4 | Taken together, these findings suggested that Daph plays a pivotal role in liver protection by suppressing inflammatory responses which may be closely associated with the inhibition of NLRP3 inflammasome, MAPK and NF-kappaB activation, as well as the induction of autophagy. | daphnetin | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |