Title : Cartilage repair in degenerative osteoarthritis mediated by squid type II collagen via immunomodulating activation of M2 macrophages, inhibiting apoptosis and hypertrophy of chondrocytes.

Pub. Date : 2018 Oct

PMID : 30031224






1 Functional Relationships(s)
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1 Our in vitro data show that SCII induces M2 polarization of macrophages, and activates macrophages to express pro-chondrogenic genes (TGF-beta and IGF), which greatly improves the microenvironment around chondrocytes to produce type II collagen and glycosaminoglycan. Glycosaminoglycans transforming growth factor, beta 1 Rattus norvegicus