Pub. Date : 2019 Jan
PMID : 30031146
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes. | Calcifediol | cytochrome P450, family 27, subfamily b, polypeptide 1 | Mus musculus |
| 2 | Daily treatment with 25(OH)D3 at 250 mug kg-1 day-1 rescued rachitic phenotypes in the Cyp27b1 KO mice. | Calcifediol | cytochrome P450, family 27, subfamily b, polypeptide 1 | Mus musculus |
| 3 | The curative effect of 25(OH)D3 was considered to depend on the de novo synthesis of 1,25(OH)2D3 in the Cyp27b1 KO mice. | Calcifediol | cytochrome P450, family 27, subfamily b, polypeptide 1 | Mus musculus |
| 4 | Interestingly, the liver mitochondrial fraction prepared from Cyp27b1 KO mice converted 25(OH)D3 to 1,25(OH)2D3. | Calcifediol | cytochrome P450, family 27, subfamily b, polypeptide 1 | Mus musculus |