Protein Name cytochrome P450, family 27, subfamily b, polypeptide 1
Organism Mus musculus
Gene ID 13115
Gene Symbol


UniProt O35084 (CP27B_MOUSE), Q66JY8 (Q66JY8_MOUSE)
Relationships Total Number of functionally related compound(s) : 92
Total Number of Articles : 159

cytochrome P450, family 27, subfamily b, polypeptide 1

Gene Summary

Enables calcidiol 1-monooxygenase activity. Involved in calcitriol biosynthetic process from calciol; response to vitamin D; and vitamin D catabolic process. Acts upstream of or within calcium ion transport. Located in mitochondrion. Is expressed in several structures, including lower jaw molar; metanephros; and testis. Used to study rickets. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

  • 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
  • 1alpha(OH)ase
  • 25(OH)D 1alpha-hydroxylase
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