Pub. Date : 2019 Mar
PMID : 30030687
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NRAL mediates cisplatin resistance in hepatocellular carcinoma via miR-340-5p/Nrf2 axis. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | A novel lncRNA, termed NRAL (Nrf2 regulation-associated lncRNA), was identified, and the initial results indicated that it was highly expressed in HepG2 cisplatin resistant cell lines compared to their parental counterparts. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Mechanistically, the results indicated that NRAL regulates Nrf2 expression through miR-340-5p serving as a competing endogenous RNA (ceRNA), thus influencing the CDDP-induced phenotype in HCC. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Collectively, the present investigation suggest that the NRAL/miR-340-5p/Nrf2 axis mediates cisplatin resistance in HCC, which may provide novel targets for overcoming cisplatin resistance in hepatocellular carcinoma cells. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 5 | Collectively, the present investigation suggest that the NRAL/miR-340-5p/Nrf2 axis mediates cisplatin resistance in HCC, which may provide novel targets for overcoming cisplatin resistance in hepatocellular carcinoma cells. | Cisplatin | NFE2 like bZIP transcription factor 2 | Homo sapiens |