Pub. Date : 2018 Jul 20
PMID : 30030468
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2C9 and OATP1B1 genetic polymorphisms affect the metabolism and transport of glimepiride and gliclazide. | Gliclazide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The aim of this study was to assess the effect of CYP2C9 and OATP1B1 genetic polymorphisms on the metabolism and transport of glimepiride and gliclazide. | Gliclazide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Glimepiride in the presence of CYP2C9*1, *2 and *3 recombinase had Vmax values of 21.58 +- 7.78, 15.69 +- 5.59, and 9.17 +- 3.03 nmol/min/mg protein, while gliclazide had Vmax values of 15.73 +- 3.11, 10.53 +- 4.06, and 6.21 +- 2.94 nmol/min/mg protein, respectively. | Gliclazide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | The clearance of glimepiride and gliclazide in CYP2C9*2 and *3 was significantly reduced compared to the wild-type. | Gliclazide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | These findings collectively indicate that OATP1B1*5 and *15 and CYP2C9*2 and *3 have a significant effect on the transport and metabolism of glimepiride and gliclazide. | Gliclazide | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |