Pub. Date : 2018 Jul
PMID : 30022161
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We identify the tumour suppressor TET2 as a substrate of the AMP-activated kinase (AMPK), which phosphorylates TET2 at serine 99, thereby stabilizing the tumour suppressor. | Serine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | We identify the tumour suppressor TET2 as a substrate of the AMP-activated kinase (AMPK), which phosphorylates TET2 at serine 99, thereby stabilizing the tumour suppressor. | Serine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Increased glucose levels impede AMPK-mediated phosphorylation at serine 99, which results in the destabilization of TET2 followed by dysregulation of both 5-hydroxymethylcytosine (5hmC) and the tumour suppressive function of TET2 in vitro and in vivo. | Serine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Treatment with the anti-diabetic drug metformin protects AMPK-mediated phosphorylation of serine 99, thereby increasing TET2 stability and 5hmC levels. | Serine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |