Pub. Date : 2019 Mar
PMID : 30021675
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. | Acetaminophen | sirtuin 2 | Mus musculus |
| 2 | Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. | Acetaminophen | sirtuin 2 | Mus musculus |
| 3 | We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). | Acetaminophen | sirtuin 2 | Mus musculus |
| 4 | This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries. | Acetaminophen | sirtuin 2 | Mus musculus |