Title : Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction.

Pub. Date : 2018 Oct

PMID : 30019466






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction. Trimetazidine matrix metallopeptidase 9 Mus musculus
2 We found that the expression of metalloproteinase (MMP) -2 and MMP-9 in the TMZ-treated group was significantly lower than the saline-treated group. Trimetazidine matrix metallopeptidase 9 Mus musculus
3 TMZ prevents CR through inhibition of oxidative stress, which is attributable to the down-regulation of MMP-2, MMP-9 expression. Trimetazidine matrix metallopeptidase 9 Mus musculus
4 CONCLUSIONS: Our findings indicate that TMZ suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents CR in mice with MI. Trimetazidine matrix metallopeptidase 9 Mus musculus