Title : ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.

Pub. Date : 2018 Sep

PMID : 30015875






3 Functional Relationships(s)
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1 Furthermore, when combined with 2-deoxyglucose (2-DG), the anticancer effect of the Bcl-2 inhibitor ABT737 was greatly potentiated and hypoxia-inducible factor 1alpha (HIF-1alpha) appeared to be closely associated with Bcl-2 family members in the regulation of glucose metabolism. Glucose BCL2 apoptosis regulator Homo sapiens
2 Furthermore, when combined with 2-deoxyglucose (2-DG), the anticancer effect of the Bcl-2 inhibitor ABT737 was greatly potentiated and hypoxia-inducible factor 1alpha (HIF-1alpha) appeared to be closely associated with Bcl-2 family members in the regulation of glucose metabolism. Glucose BCL2 apoptosis regulator Homo sapiens
3 These results suggested that the special glucose metabolism in SKOV3/DDP cells might be selectively targeted by disrupting Bcl-2-dependent OXPHOS. Glucose BCL2 apoptosis regulator Homo sapiens