Title : Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest.

Pub. Date : 2018 Oct 1

PMID : 30009775






3 Functional Relationships(s)
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1 In this study, the results illustrated that DMC induced Reactive oxygen species (ROS) leads to reduced expression of CDC25C, Cyclin B1 and CDK1 (Thr161) triggers G2/M cell cycle arrest in U87 MG glioma cells. methyl carbonate cyclin dependent kinase 1 Homo sapiens
2 To explore the possibility of direct involvement of DMC in the dissociation of CDK1/Cyclin B1 complex, the molecular docking and MD simulation studies were carried. methyl carbonate cyclin dependent kinase 1 Homo sapiens
3 The results showed that DMC nicely fitted into the binding site of CDK1 and Cyclin B1 with minimum binding energy (DeltaG) of -9.46 kcal/mol (Ki = 0.11 muM) and - 9.90 kcal/mol (Ki = 0.05 muM) respectively. methyl carbonate cyclin dependent kinase 1 Homo sapiens