Pub. Date : 2018 Aug
PMID : 30008817
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/beta-catenin signaling pathway. | icariin | catenin beta 1 | Homo sapiens |
| 2 | The present study was conducted to investigate the effects of icariin (ICA) on osteosarcoma cell proliferation and to investigate the role of the Wnt/beta-catenin signaling pathway in the inhibition process of ICA on osteosarcoma cell proliferation. | icariin | catenin beta 1 | Homo sapiens |
| 3 | The expression levels of related and apoptotic proteins in the Wnt/beta-catenin signaling pathway using ICA were detected by semi-quantitative PCR and western blot analysis, respectively. | icariin | catenin beta 1 | Homo sapiens |
| 4 | Semi-quantitative PCR and western blot analysis revealed that the expression levels of p-GSK3beta, beta-catenin, c-Myc and cyclin D1 in cells after ICA treatment were significantly downregulated (p<0.01), while the expression level of caspase-3 was significantly increased (p<0.01). | icariin | catenin beta 1 | Homo sapiens |
| 5 | Thus, ICA can significantly inhibit osteosarcoma cell proliferation and promote osteosarcoma cell apoptosis, which may be realized by affecting the expression of the Wnt/beta-catenin signaling pathway and blocking the expression of related proteins. | icariin | catenin beta 1 | Homo sapiens |