Pub. Date : 2018
PMID : 30002810
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington"s disease. | Iron | aconitase 1 | Mus musculus |
| 2 | Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin. | Iron | aconitase 1 | Mus musculus |
| 3 | Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex. | Iron | aconitase 1 | Mus musculus |
| 4 | Conclusion: We conclude that mutant huntingtin may cause abnormal iron homeostatic pathways by increasing IRP1 expression in Huntington"s disease, suggesting potential therapeutic target. | Iron | aconitase 1 | Mus musculus |