PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30002810-0	2018	Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington"s disease.	Iron	26-30	aconitase 1	Mus musculus	58-62	
30002810-5	2018	Iron homeostatic proteins including iron response protein 1 (IRP1), transferrin (Tf), ferritin and transferrin receptor (TfR) were determined by using western blotting and immunohistochemistry, and their relative expression levels of RNA were measured by RT-PCR in both N171-82Q HD transgenic mice and HEK293 cells expressing N-terminal of huntingtin.	Iron	0-4	aconitase 1	Mus musculus	36-59	
30002810-7	2018	Analysis of iron homeostatic proteins revealed increased expression of IRP1, Tf, ferritin and TfR in N171-82Q mice striatum and cortex.	Iron	12-16	aconitase 1	Mus musculus	71-75	
30002810-9	2018	Conclusion: We conclude that mutant huntingtin may cause abnormal iron homeostatic pathways by increasing IRP1 expression in Huntington"s disease, suggesting potential therapeutic target.	Iron	66-70	aconitase 1	Mus musculus	106-110