Title : Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages.

Pub. Date : 2018

PMID : 29973940






1 Functional Relationships(s)
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1 Activation of the GPR84 receptor with a selective agonist, 6-(octylamino) pyrimidine-2,4(1H,3H)-dione (6-n-octylaminouracil, 6-OAU), enhanced the expression of phosphorylated Akt, p-ERK, and p65 nuclear translocation under inflammatory conditions and elevated the expression levels of the inflammatory mediators TNFalpha, IL-6, IL-12B, CCL2, CCL5, and CXCL1. 6-(octylamino) pyrimidine-2,4(1h,3h)-dione interleukin 6 Mus musculus