Pub. Date : 2018 Dec
PMID : 29961403
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2-ARE pathway. | Rosuvastatin Calcium | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 2 | METHODS: In silico studies were performed to check the theoretical binding of rosuvastatin to the Nrf2 target. | Rosuvastatin Calcium | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | RESULTS: Rosuvastatin showed good theoretical affinity to Nrf2, significantly reversed changes in oxidative biomarkers which were induced by HSCD, and also improved the performance of rats in the neurobehavioral test. | Rosuvastatin Calcium | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 4 | DISCUSSION: We have investigated a novel mechanism of action for rosuvastatin (via the Nrf2-ARE pathway) and demonstrated that it has the potential to be used in the treatment of cognitive impairment. | Rosuvastatin Calcium | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |