Pub. Date : 2018 Sep
PMID : 29959200
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The second, arsenic trioxide (ATO), at therapeutically achievable concentrations, reduces the level of FLT3-ITD and Mcl-1 proteins, and induces apoptosis in leukemic cell lines and in primary cells expressing FLT3-ITD. | Arsenic Trioxide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | The second, arsenic trioxide (ATO), at therapeutically achievable concentrations, reduces the level of FLT3-ITD and Mcl-1 proteins, and induces apoptosis in leukemic cell lines and in primary cells expressing FLT3-ITD. | Arsenic Trioxide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | When ATO is combined with Sorafenib, GSK3beta is activated, Mcl-1 is further reduced, and proapoptotic proteins Bak and Bax are activated. | Arsenic Trioxide | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |