Title : Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells.

Pub. Date : 2018 Oct 1

PMID : 29959144






1 Functional Relationships(s)
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1 Treatment of established lines and primary ovarian cancer cultures with Src and MEK inhibitors saracatinib and selumetinib, respectively, showed target kinase inhibition and synergistic induction of apoptosis and cell-cycle arrest in vitro, and tumor inhibition in xenografts. saracatinib SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens