Pub. Date : 2019 Feb
PMID : 29948949
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, we showed that arsenic (0.38 mg/kg body weight) exposure induces microglial activation and consequently IL-6/TNF-alpha secretion. | Arsenic | interleukin 6 | Mus musculus |
| 2 | Higher CD68 staining, increased level of IL-6/TNF-alpha, as well as higher level of IFNgamma, were observed in in vivo arsenic-exposed groups. | Arsenic | interleukin 6 | Mus musculus |
| 3 | Finally, intracerebral injection of anti-IFNgamma neutralizing antibody in arsenic-exposed brain reduced microglia activation (IL-6 and TNF-alpha and CD68 expression) and subsequently rescued CD200 level. | Arsenic | interleukin 6 | Mus musculus |
| 4 | Taken together, the study showed that arsenic-mediated compromised blood-brain barrier is a major driving force to induce microglial IL-6 and TNF-alpha production through serum IFNgamma leading to CD200 downregulation. | Arsenic | interleukin 6 | Mus musculus |