Title : Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.

Pub. Date : 2018 Sep

PMID : 29945292






2 Functional Relationships(s)
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1 EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model. imperatorin nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model. imperatorin nuclear receptor subfamily 1 group I member 2 Homo sapiens