Pub. Date : 2018 Sep
PMID : 29945292
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model. | imperatorin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |
2 | EXPERIMENTAL APPROACH: The effects of IMP on PXR-modulated cytochrome P450 3A4 (CYP3A4) expression were assessed using a PXR transactivation assay, a mammalian two-hybrid assay, a competitive ligand-binding assay, analysis of CYP3A4 mRNA and protein expression levels and measurement of CYP3A4 activity using a cell-based reporter gene assay and in vitro model. | imperatorin | nuclear receptor subfamily 1 group I member 2 | Homo sapiens |