Title : HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer.

Pub. Date : 2018 Aug 1

PMID : 29939161






1 Functional Relationships(s)
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1 CONCLUSION: Increased generation of 3-keto-5alpha-abiraterone in patients with HSD3B1(1245C) might partially negate abiraterone benefits in these patients who are otherwise more likely to benefit from CYP17A1 inhibition. abiraterone cytochrome P450 family 17 subfamily A member 1 Homo sapiens