Title : 18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma.

Pub. Date : 2018 Jun 19

PMID : 29921924






2 Functional Relationships(s)
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1 We compared the roles of the ATF4/CHOP and IRE1alpha/XBP1s UPR pathways, which were both induced by GA. 18alpha-glycyrrhetinic acid DNA damage inducible transcript 3 Homo sapiens
2 The ATF4/CHOP cascade induced autophagy and was indispensable for the induction of apoptosis in GA-treated HCC cells. 18alpha-glycyrrhetinic acid DNA damage inducible transcript 3 Homo sapiens