Title : The Role of Water in the Stability of Wild-type and Mutant Insulin Dimers.

Pub. Date : 2018 Jul 19

PMID : 29916244






1 Functional Relationships(s)
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1 Consistent with experiments, it is found that the Gly and Ala modifications lead to insulin dimers with reduced stability by 4 and 5 kcal/mol from thermodynamic integration and 4 and 8 kcal/mol from results using molecular mechanics-generalized Born surface area, respectively. Glycine insulin Homo sapiens