Pub. Date : 2018 Sep 28
PMID : 29913235
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | The present study aimed to investigate the pathway related to MCL1 expression in ABT-263-treated human leukemia U937 cells. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | ABT-263 upregulated MCL1 protein expression but did not affect its mRNA level and protein stability. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Overexpression of 4EBP1 abrogated ABT-263-induced MCL1 upregulation. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 5 | Inhibition of the IKKalpha/beta-NFkappaB axis or autophagy mitigated the effect of ABT-263 on 4EBP1 and MCL1 expression. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 6 | Our data indicate that ABT-263 alleviates the inhibitory effect of 4EBP1 on MCL1 protein synthesis through IKKalpha/beta-NFkappaB-mediated induction of autophagy, and suggest a promising strategy to improve anti-leukemia therapy with ABT-263. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 7 | Our data indicate that ABT-263 alleviates the inhibitory effect of 4EBP1 on MCL1 protein synthesis through IKKalpha/beta-NFkappaB-mediated induction of autophagy, and suggest a promising strategy to improve anti-leukemia therapy with ABT-263. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |