Title : Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes.

Pub. Date : 2018 Aug 20

PMID : 29909290






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes H2O2 also elevated REDD1 mRNA levels. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens
2 REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes H2O2 also elevated REDD1 mRNA levels. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens
3 REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes H2O2 also elevated REDD1 mRNA levels. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens
4 REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes H2O2 also elevated REDD1 mRNA levels. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens
5 Furthermore, we observed that REDD1 overexpression attenuated H2O2 or t-BHP-derived reactive oxygen species formation as well as cytotoxicity. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens
6 Conversely, siRNA against REDD1 aggravated t-BHP-induced reactive oxygen species generation and cell death. tert-Butylhydroperoxide DNA damage inducible transcript 4 Homo sapiens