Pub. Date : 2018 Aug
PMID : 29884546
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease. | Alcohols | toll-like receptor 4 | Mus musculus |
| 2 | RESULTS: We found that selective hepatocyte TLR4 deletion protected mice from chronic alcohol-induced liver injury and fatty liver. | Alcohols | toll-like receptor 4 | Mus musculus |
| 3 | Furthermore, in an acute alcohol binge model, hepatocyte TLR4 deficient mice had significantly decreased plasma alanine transaminase (ALT) levels and attenuated hepatic triglyceride content compared to their alcohol-gavaged control mice. | Alcohols | toll-like receptor 4 | Mus musculus |
| 4 | CONCLUSIONS: These findings suggest that hepatocyte TLR4 plays an important role in regulating alcohol-induced liver damage and fatty liver disease. | Alcohols | toll-like receptor 4 | Mus musculus |