Pub. Date : 2018 Jun 5
PMID : 29874838
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methyl 3,4-Dihydroxybenzoate Enhances Resistance to Oxidative Stressors and Lifespan in C. elegans Partially via daf-2/daf-16. | methyl 3,4-dihydroxybenzoate | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase | Caenorhabditis elegans |
| 2 | Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans. | methyl 3,4-dihydroxybenzoate | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase | Caenorhabditis elegans |
| 3 | Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans. | methyl 3,4-dihydroxybenzoate | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase | Caenorhabditis elegans |
| 4 | Surprisingly, the life-span-extending activity of MDHB is completely abolished in daf-2 (e1370) mutations, which suggests that daf-2 is crucial for a MDHB-induced pro-longevity effect in C. elegans. | methyl 3,4-dihydroxybenzoate | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase | Caenorhabditis elegans |
| 5 | Therefore, our results indicate that MDHB at least partially acts as a modulator of the daf-2/daf-16 pathway to extend the lifespan of C. elegans, and MDHB might be a promising therapeutic agent for age-related diseases. | methyl 3,4-dihydroxybenzoate | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase | Caenorhabditis elegans |