| Protein Name | Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase |
|---|---|
| Organism | Caenorhabditis elegans |
| Gene ID | 175410 |
| Gene Symbol | daf-2 |
| UniProt | Q968Y9 (INSR_CAEEL), A0A0K3AUA1 (A0A0K3AUA1_CAEEL), A0A0K3ARE8 (A0A0K3ARE8_CAEEL), A0A0K3ARZ1 (A0A0K3ARZ1_CAEEL), A0A0K3AUY1 (A0A0K3AUY1_CAEEL), A0A0K3AXA0 (A0A0K3AXA0_CAEEL) |
| Relationships |
Total Number of functionally related compound(s) :
93
Total Number of Articles : 117 |
Description |
Insulin-like receptor subunit beta;Protein kinase domain-containing protein;receptor protein-tyrosine kinase |
| Gene Summary |
Enables PTB domain binding activity; SH2 domain binding activity; and protein kinase binding activity. Involved in several processes, including dauer exit; larval feeding behavior; and regulation of gene expression. Acts upstream of with a negative effect on protein import into nucleus. Located in several cellular components, including axon; neuronal cell body; and non-motile cilium. Is spanning component of plasma membrane. Is expressed in gonad; hypodermis; intestine; and nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); diabetes mellitus (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022] |
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