Pub. Date : 2018 Sep
PMID : 29859874
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on its unique tertiary structure, we explored the potential of NAA to modulate aggregation of amyloid-beta (Abeta) peptide 1-42 via multiple corroborating aggregation assays along with electron microscopy. | N-acetylaspartate | amyloid beta precursor protein | Homo sapiens |
| 2 | Thioflavin-T fluorescence assay demonstrated that at physiological concentrations, NAA substantially inhibited the initiation of Abeta fibril formation. | N-acetylaspartate | amyloid beta precursor protein | Homo sapiens |
| 3 | Furthermore, fluorescence correlation spectroscopy and dynamic light scattering measurements confirmed significant reductions in Abeta fibril hydrodynamic radius following treatment with NAA. | N-acetylaspartate | amyloid beta precursor protein | Homo sapiens |