Title : [Tyrosyl-DNA phosphodiesterases: potential targets for cancer treatment].

Pub. Date : 2016 Feb

PMID : 29856574






1 Functional Relationships(s)
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Protein Name
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1 TDP1 and TDP2 have the ability to hydrolyze the tyrosyl-phosphodiester bond of the phenol of tyrosine with 3"- and 5"-DNA end, respectively, which are contained in the metabolites of the damaged DNA mediated by topoisomerase 1 and topoisomerase 2, respectively. Tyrosine tyrosyl-DNA phosphodiesterase 1 Homo sapiens