Pub. Date : 2018 May 29
PMID : 29844375
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 2 | A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 3 | A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 4 | A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 5 | A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 6 | We herein demonstrate that ganglioside expression is inducible in Drosophila via the expression of transgenes of ganglioside synthesis enzymes and the feeding of exogenous sialic acid, and also that the induction of ganglioside synthesis significantly accelerates Abeta assembly in vivo. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |
| 7 | Our results support the hypothesis that gangliosides are responsible for Abeta assembly in vivo and also provide an opportunity to develop a valuable model for basic research as well as a therapeutic strategy for AD. | Gangliosides | beta amyloid protein precursor-like | Drosophila melanogaster |