Protein Name beta amyloid protein precursor-like
Organism Drosophila melanogaster
Gene ID 31002
Gene Symbol

Appl

UniProt P14599 (A4_DROME), M9NE22 (M9NE22_DROME), M9NFQ0 (M9NFQ0_DROME), M9NDH5 (M9NDH5_DROME), M9NGF6 (M9NGF6_DROME), M9NEM2 (M9NEM2_DROME)
Relationships Total Number of functionally related compound(s) : 53
Total Number of Articles : 48
Description

beta amyloid protein precursor-like

Gene Summary

Predicted to enable heparin binding activity and transition metal ion binding activity. Involved in several processes, including memory; negative regulation of neuron death; and nervous system development. Located in several cellular components, including axon; extracellular region; and neuronal cell body. Is expressed in several structures, including adult Malpighian tubule; adult fat body; anterior-posterior subdivision of organism; nervous system; and pupal/adult digestive system. Used to study Alzheimer's disease and Alzheimer's disease 1. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to several human genes including APLP2 (amyloid beta precursor like protein 2) and APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • beta amyloid protein precursor-like
  • APP-like
  • Appl-PA
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Properties