Pub. Date : Spring 2018
PMID : 29808689
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have demonstrated a reduced sensitivity of MT-3 transfected cells to CDDP (24h IC50 of 7.48 +- 0.97 and 19.81 +- 1.2 mug/ml), a higher number of colonies after incubation with CDDP, reduced caspase 3 after incubation with CDDP and lower free oxygen radicals after induction of CDDP. | cddp | metallothionein 3 | Homo sapiens |
| 2 | We have demonstrated a reduced sensitivity of MT-3 transfected cells to CDDP (24h IC50 of 7.48 +- 0.97 and 19.81 +- 1.2 mug/ml), a higher number of colonies after incubation with CDDP, reduced caspase 3 after incubation with CDDP and lower free oxygen radicals after induction of CDDP. | cddp | metallothionein 3 | Homo sapiens |
| 3 | We have demonstrated a reduced sensitivity of MT-3 transfected cells to CDDP (24h IC50 of 7.48 +- 0.97 and 19.81 +- 1.2 mug/ml), a higher number of colonies after incubation with CDDP, reduced caspase 3 after incubation with CDDP and lower free oxygen radicals after induction of CDDP. | cddp | metallothionein 3 | Homo sapiens |
| 4 | We have demonstrated a reduced sensitivity of MT-3 transfected cells to CDDP (24h IC50 of 7.48 +- 0.97 and 19.81 +- 1.2 mug/ml), a higher number of colonies after incubation with CDDP, reduced caspase 3 after incubation with CDDP and lower free oxygen radicals after induction of CDDP. | cddp | metallothionein 3 | Homo sapiens |
| 5 | CONCLUSION: We have demonstrated the relationship between MT-3 and senescence-induced oncogene genes and some other genes relevant to cell fate (glutathione S-transferase M3, caspase 4 and DNAJB6) and a significant proportion of MT-3 on CDDP resistance. | cddp | metallothionein 3 | Homo sapiens |