Pub. Date : 2018 May 22
PMID : 29804421
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both DAPT and curcumin-PDT can inhibit the protein expression of Notch1, NF-kappaB and VEGF, and two of them have synergistic effect after combined use. | dapt | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. | dapt | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | Conclusions: DAPT can effectively block the Notch signaling pathway and inhibit the proliferation of cervical cancer cell line Me180.The application of DAPT to inhibit Notch signaling pathway after photodynamic therapy can achieve synergistic effect, which is mainly related to the down-regulation of the expression of Notch1 and NF-kappaB.Notch signaling pathway may be one of the targets of curcumin-PDT photodynamic therapy. | dapt | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |