Title : Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation.

Pub. Date : 2018 Jun

PMID : 29804278






1 Functional Relationships(s)
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1 The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway. tert-Butylhydroperoxide NFE2 like bZIP transcription factor 2 Homo sapiens