Title : SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation.

Pub. Date : 2018 Oct 1

PMID : 29803744






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1 Oxidative stress has long been considered to be harmful to cells, nevertheless, in this study, we found that lower concentration of hydrogen peroxide (H2O2) decreased the number of SA-betagal-immunopositive cells, which was ameliorated by inhibition of SIRT1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine sirtuin 1 Homo sapiens