Pub. Date : 2018 Aug 15
PMID : 29802833
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha and TNF-R1 regulate bupivacaine-induced apoptosis in spinal cord dorsal root ganglion neuron. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 2 | This study used an in vitro model to explore the expression and function of tumor necrosis factor (TNF) signaling pathway in bupivacaine-induced apoptotic injury in spinal cord dorsal root ganglia (DRG). | Bupivacaine | tumor necrosis factor | Mus musculus |
| 3 | This study used an in vitro model to explore the expression and function of tumor necrosis factor (TNF) signaling pathway in bupivacaine-induced apoptotic injury in spinal cord dorsal root ganglia (DRG). | Bupivacaine | tumor necrosis factor | Mus musculus |
| 4 | QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 5 | QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 6 | QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 7 | QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 8 | SiRNA-mediated TNF-alpha or TNF-R1 inhibition, but not TNF-R2 inhibition, rescued bupivacaine-induced DRG apoptosis. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 9 | In addition, qRT-PCR and western blot demonstrated that downstream substrates of apoptotic and TNF signaling pathways, caspase-9, MAP3K and JNK, were all significantly downregulated by TNF-alpha or TNF-R1 inhibition, but not by TNF-R2 inhibition, in bupivacaine-injured DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |
| 10 | In addition, qRT-PCR and western blot demonstrated that downstream substrates of apoptotic and TNF signaling pathways, caspase-9, MAP3K and JNK, were all significantly downregulated by TNF-alpha or TNF-R1 inhibition, but not by TNF-R2 inhibition, in bupivacaine-injured DRG. | Bupivacaine | tumor necrosis factor | Mus musculus |