Title : Can crocin play a preventive role in Wistar rats with carbon tetrachloride-induced nephrotoxicity?

Pub. Date : 2018 Apr

PMID : 29796221






2 Functional Relationships(s)
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1 Results: In the CCl4 administered group, MDA, TOS, Bun, and creatinine levels increased, GSH, SOD, CAT, and TAS levels decreased (P<=0.05), glomerular collapse in kidney sections, narrowing and local occlusion in Bowman"s space in certain glomeruli, inflammatory cell infiltration and congestion were observed when compared to all other groups. Glutathione C-C motif chemokine ligand 4 Rattus norvegicus
2 There was a significant decrease in increased MDA, TOS, Bun, and creatinine levels, and a significant increase in decreased GSH, SOD, CAT, and TAS levels in CCl4 + crocin administered group compared to the CCl4 group (P<=0.05), local minimal glomerular damage, tubular damage, inflammatory infiltration, and vascular collagen symptoms were observed in kidney sections, however significant improvement was observed in damage findings when compared to the CCl4 group. Glutathione C-C motif chemokine ligand 4 Rattus norvegicus