Title : Oncodriver inhibition and CD4+ Th1 cytokines cooperate through Stat1 activation to induce tumor senescence and apoptosis in HER2+ and triple negative breast cancer: implications for combining immune and targeted therapies.

Pub. Date : 2018 May 1

PMID : 29796172

2 Functional Relationships(s)
Compound Name
Protein Name
1 TNF-alpha and IFN-gamma led to increased Stat1 phosphorylation through serine and tyrosine sites and a compensatory reduction in Stat3 activation. Tyrosine interferon gamma Homo sapiens
2 Single agent IFN-gamma enhanced Stat1 phosphorylation on tyrosine 701 and similar effects were observed in combination with TNF-alpha and EGFR inhibition. Tyrosine interferon gamma Homo sapiens