Pub. Date : 2018 May 23
PMID : 29795117
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. | Cysteine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Key to NRF2 activation is the ability to chemically modifying critical sensor cysteines in the main negative regulator of NRF2, Kelch-like ECH-associated protein 1 (KEAP1), of which C151, C273 and C288 are best characterized. | Cysteine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Key to NRF2 activation is the ability to chemically modifying critical sensor cysteines in the main negative regulator of NRF2, Kelch-like ECH-associated protein 1 (KEAP1), of which C151, C273 and C288 are best characterized. | Cysteine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | This study aimed to establish the requirement for these cysteine sensor(s) for the biological activities of the most potent NRF2 activators known to date, the cyclic cyanoenones, some of which are in clinical trials. | Cysteine | NFE2 like bZIP transcription factor 2 | Homo sapiens |