Title : Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice.

Pub. Date : 2018 Jan

PMID : 29793313






2 Functional Relationships(s)
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1 In addition, phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway in Pilo-induced acute seizures was also inactivated by scoparone. scoparone thymoma viral proto-oncogene 1 Mus musculus
2 In vitro, we confirmed that scoparone inhibited LPS-caused astrocytes activation as proved by the reduced glial fibrillary acidic protein (GFAP) levels, inflammation and apoptosis, which were at least partly dependent on AKT suppression. scoparone thymoma viral proto-oncogene 1 Mus musculus