Pub. Date : 2018 Jun 14
PMID : 29792703
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) required for androgen biosynthesis. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Abiraterone is a clinical first-in-class inhibitor of cytochrome P450 17A1 (CYP17A1) required for androgen biosynthesis. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Abiraterone analogs were designed based on structural evidence that B-ring substituents may favorably interact with polar residues in binding CYP17A1 and sterically clash with residues in the CYP21A2 active site. | abiraterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |