Title : Select α-arrestins control cell-surface abundance of the mammalian Kir2.1 potassium channel in a yeast model.

Pub. Date : 2018 Jul 13

PMID : 29784874






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Kir2.1 maintains potassium homeostasis in heart muscle cells, and Kir2.1 defects lead to human disease. Potassium potassium inwardly rectifying channel subfamily J member 2 Homo sapiens
2 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium potassium inwardly rectifying channel subfamily J member 2 Homo sapiens
3 Specifically, we found that the Ldb19/Art1, Aly1/Art6, and Aly2/Art3 alpha-arrestin adaptor proteins promote Kir2.1 trafficking to the cell surface, increase Kir2.1 activity at the plasma membrane, and raise intracellular potassium levels. Potassium potassium inwardly rectifying channel subfamily J member 2 Homo sapiens