Pub. Date : 2018 Aug
PMID : 29784660
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that IL-6 couples autophagy to antioxidant response and thereby reduces ROS in beta-cells and human islets. | Reactive Oxygen Species | interleukin 6 | Homo sapiens |
| 2 | IL-6-driven ROS reduction is associated with an increase in the master antioxidant factor NRF2, which rapidly translocates to the mitochondria to decrease mitochondrial activity and stimulate mitophagy. | Reactive Oxygen Species | interleukin 6 | Homo sapiens |
| 3 | IL-6 also initiates a robust transient decrease in cellular cAMP levels, likely contributing to the stimulation of mitophagy to mitigate ROS. | Reactive Oxygen Species | interleukin 6 | Homo sapiens |