Title : Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension.

Pub. Date : 2018 Jul-Sep

PMID : 29767573






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Consistent with our hypothesis, mice that received the IL-6 trans-signaling-specific inhibitor sgp130Fc, a fusion protein of the soluble extracellular portion of gp130 with the constant portion of the mouse IgG1 antibody, showed attenuation of CH-induced increases in right ventricular systolic pressure, right ventricular and pulmonary arterial remodeling as compared to vehicle (saline)-treated control mice. Sodium Chloride interleukin 6 Mus musculus