Pub. Date : 2018 Jun
PMID : 29754213
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Puri-Li kinetic model is modified to include neuronal calcium ion homeostasis to study the effect of calcium ions on the production of amyloid-beta peptides (Abeta), microglia, and astroglia during the pathogenesis of Alzheimer"s disease (AD). | Calcium | amyloid beta precursor protein | Homo sapiens |
| 2 | The derived expressions show that the inclusion of calcium ions has altered the steady-state populations of Abeta, microglia, and astroglia. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 3 | The calcium ions activate the synthesis of Abeta which in turn increases the calcium ions entering the cytoplasm of the neuronal cells, thus creating a positive loop. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 4 | The calcium ions activate the synthesis of Abeta which in turn increases the calcium ions entering the cytoplasm of the neuronal cells, thus creating a positive loop. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 5 | These model results are in agreement with experimental findings, which show a feed back loop between calcium ion levels and Abeta; population increase in microglia, astroglia during AD; and microglia, astroglia acting as inflammatory cells producing toxins to destroy neurons during AD. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 6 | Increased production of Abeta, microglia, and astroglia resulting from increased levels of calcium ions suggests that controlling the calcium ion levels could present a therapeutic strategy to combat AD. | Calcium | amyloid beta precursor protein | Homo sapiens |
| 7 | Increased production of Abeta, microglia, and astroglia resulting from increased levels of calcium ions suggests that controlling the calcium ion levels could present a therapeutic strategy to combat AD. | Calcium | amyloid beta precursor protein | Homo sapiens |